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Literature summary for 2.4.1.17 extracted from
- Isolation and purification of rat liver morphine UDP-glucuronosyltransferase (1986), Mol. Pharmacol., 30, 558-565.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| codeine | competitive inhibitor to morphine-UDPGT | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 56000 | - |
morphine-UDPGT, monomer | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
Wistar strain | - |
| Rattus norvegicus Wistar | - |
Wistar strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxybiphenyl + UDP-glucuronate | no activity | Rattus norvegicus | UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide | - |
? | |
| 4-hydroxybiphenyl + UDP-glucuronate | no activity | Rattus norvegicus Wistar | UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide | - |
? | |
| alpha-naphthylamine + UDPglucuronate | inactive | Rattus norvegicus | UDP + ? | - |
? | |
| bilirubin + UDPglucuronate | no activity | Rattus norvegicus | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
| bilirubin + UDPglucuronate | no activity | Rattus norvegicus Wistar | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
| estrone + UDPglucuronate | inactive | Homo sapiens | UDP + estrone 3-O-glucuronide | - |
? | |
| additional information | no activity with androsterone | Rattus norvegicus | ? | - |
? | |
| additional information | 36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids | Homo sapiens | ? | - |
? | |
| additional information | no activity with androsterone | Rattus norvegicus Wistar | ? | - |
? | |
| morphine + UDP-glucuronate | - |
Homo sapiens | UDP + morphine 3,6-diglucuronide | - |
? | |
| morphine + UDP-glucuronate | - |
Rattus norvegicus | UDP + morphine 3,6-diglucuronide | - |
? | |
| morphine + UDP-glucuronate | - |
Rattus norvegicus Wistar | UDP + morphine 3,6-diglucuronide | - |
? | |
| testosterone + UDPglucuronate | no activity | Homo sapiens | UDP + testosterone O-glucuronide | - |
? | |
| testosterone + UDPglucuronate | no activity | Rattus norvegicus | UDP + testosterone O-glucuronide | - |
? | |
| testosterone + UDPglucuronate | no activity | Rattus norvegicus Wistar | UDP + testosterone O-glucuronide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | by chromatofocusing | Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.1 | - |
codeine | competitive with morphine glucuronidation | Rattus norvegicus | |
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