Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Mersalyl | maximal activation towards estrone, estradiol and testosterone at 1 mM | Cavia porcellus | |
Phospholipase A | stimulation of glucuronidation of estradiol and estrone, inhibition of glucuronidation of testosterone in whole microsomes | Cavia porcellus | |
UDP-N-acetylglucosamine | no significant activation towards steroids as aglycones | Cavia porcellus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Phospholipase A | potentiates end-product inhibition in whole microsomes: inhibition of glucuronidation of testosterone, stimulation of glucuronidation of estradiol and estrone | Cavia porcellus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Cavia porcellus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | 1 mM, activation | Cavia porcellus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
domestic guinea pig | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Cavia porcellus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + UDPglucuronate | - |
Cavia porcellus | UDP + estrone 3-O-glucuronide | - |
? | |
testosterone + UDPglucuronate | - |
Cavia porcellus | UDP + testosterone O-glucuronide | - |
? |