Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.165 extracted from

  • Nguyen, H.H.; Jayasinha, V.; Xia, B.; Hoyte, K.; Martin, P.T.
    Overexpression of the cytotoxic T cell GalNAc transferase in skeletal muscle inhibits muscular dystrophy in mdx mice (2002), Proc. Natl. Acad. Sci. USA, 99, 5616-5621.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.165

Cloned(Commentary)

Cloned (Comment) Organism
transgenic mice overexpress the enzyme in the skeletal muscle of mdx animals Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide Mus musculus overexpression of the enzyme in skeletal muscles inhibits muscular dystrophy in mdx mice. The enzyme produces the terminal beta1,4GalNAc linkage on the cytotoxic T cell carbohydrate antigen which is also localized to the neuromuscular junction in adult animals UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide overexpression of the enzyme in skeletal muscles inhibits muscular dystrophy in mdx mice. The enzyme produces the terminal beta1,4GalNAc linkage on the cytotoxic T cell carbohydrate antigen which is also localized to the neuromuscular junction in adult animals Mus musculus UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?