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Literature summary for 2.4.1.16 extracted from

  • Li, B.; Shen, Y.; Wu, H.; Wu, X.; Yuan, L.; Ji, Q.
    Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents (2020), Eur. J. Med. Chem., 195, 112278 .
    View publication on PubMed
Search for more literature for 2.4.1.16

Inhibitors

Inhibitors Comment Organism Structure
N1-(2-bromophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 39.9% inhibition at 0.3 mg/ml Candida tropicalis
N1-(2-chlorophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 46.7% inhibition at 0.3 mg/ml Candida tropicalis
N1-(2-fluorophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 48.9% inhibition at 0.3 mg/ml Candida tropicalis
N1-(2-methoxyphenyl)-N4-(2-oxo-12,3,4-tetrahydroquinolin-3-yl) fumaramide 82.3% inhibition at 0.3 mg/ml Candida tropicalis
N1-(2-nitrophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 53.3% inhibition at 0.3 mg/ml Candida tropicalis
N1-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-N4-(p-tolyl)fumaramide 58.7% inhibition at 0.3 mg/ml Candida tropicalis
N1-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-N4-phenylfumaramide 35.7% inhibition at 0.3 mg/ml Candida tropicalis
N1-(3,4-difluorophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 66.5% inhibition at 0.3 mg/ml Candida tropicalis
N1-(3,5-dimethylphenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 71.5% inhibition at 0.3 mg/ml Candida tropicalis
N1-(3-bromophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 45.2% inhibition at 0.3 mg/ml Candida tropicalis
N1-(3-nitrophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 49.3% inhibition at 0.3 mg/ml Candida tropicalis
N1-(4-bromophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 40.3% inhibition at 0.3 mg/ml Candida tropicalis
N1-(4-chlorophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 50.5% inhibition at 0.3 mg/ml Candida tropicalis
N1-(4-fluorophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 51.2% inhibition at 0.3 mg/ml Candida tropicalis
N1-(4-methoxyphenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 74.6% inhibition at 0.3 mg/ml Candida tropicalis
N1-(4-nitrophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 65.2% inhibition at 0.3 mg/ml Candida tropicalis
N1-(naphthalen-1-yl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide 27.8% inhibition at 0.3 mg/ml Candida tropicalis
Polyoxin B 87.5% inhibition at 0.3 mg/ml Candida tropicalis

Organism

Organism UniProt Comment Textmining
Candida tropicalis
-
-
-
Candida tropicalis ATCC 750
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-
-

Synonyms

Synonyms Comment Organism
CHS
-
 Candida tropicalis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.09
-
 at pH 7.5, temperature not specified in the publication Candida tropicalis Polyoxin B
0.16
-
 at pH 7.5, temperature not specified in the publication Candida tropicalis N1-(2-methoxyphenyl)-N4-(2-oxo-12,3,4-tetrahydroquinolin-3-yl) fumaramide
0.19
-
 at pH 7.5, temperature not specified in the publication Candida tropicalis N1-(3,5-dimethylphenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide
0.21
-
 at pH 7.5, temperature not specified in the publication Candida tropicalis N1-(4-methoxyphenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide
0.26
-
 at pH 7.5, temperature not specified in the publication Candida tropicalis N1-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-N4-(p-tolyl)fumaramide
0.32
-
 at pH 7.5, temperature not specified in the publication Candida tropicalis N1-(2-nitrophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide
0.34
-
 at pH 7.5, temperature not specified in the publication Candida tropicalis N1-(3,4-difluorophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide
0.34
-
 at pH 7.5, temperature not specified in the publication Candida tropicalis N1-(4-fluorophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide
0.35
-
 at pH 7.5, temperature not specified in the publication Candida tropicalis N1-(4-nitrophenyl)-N4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl) fumaramide