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Literature summary for 2.4.1.16 extracted from

  • Ji, Q.; Deng, Q.; Li, B.; Li, B.; Shen, Y.
    Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents (2019), Eur. J. Med. Chem., 180, 204-212 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-(4-(2-hydroxy-3-((2-methoxyphenyl)amino)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-((4-methoxyphenyl)amino)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-(1H-imidazol-1-yl)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-(4H-1,2,4-triazol-4-yl)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-(naphthalen-1-ylamino)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-(o-tolylamino)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-(p-tolylamino)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-(phenylamino)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-(piperazin-1-yl)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-(piperidin-1-yl)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-(pyrrolidin-1-yl)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(2-hydroxy-3-morpholinopropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-((2,6-dimethylphenyl)amino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-((2-chlorophenyl)amino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-((4-bromophenyl)amino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-((4-chlorobenzyl)amino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-((4-chlorophenyl)amino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-(azepan-1-yl)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-(benzylamino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-(bis(2-hydroxyethyl)amino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-(butylamino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-(diethylamino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
5-(4-(3-(tert-butylamino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
-
Saccharomyces cerevisiae
itraconazole
-
Saccharomyces cerevisiae
nikkomycin Z
-
Saccharomyces cerevisiae
Norfloxacin
-
Saccharomyces cerevisiae
Polyoxin B 85.1% inhibition at 0.3 mg/ml Saccharomyces cerevisiae
Polyoxin D
-
Saccharomyces cerevisiae
RO-09-3024
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae CGMCC 2.145
-
-
-

Synonyms

Synonyms Comment Organism
CHS
-
Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.1
-
at pH 7.5 and 37°C Saccharomyces cerevisiae 5-(4-(2-hydroxy-3-((4-methoxyphenyl)amino)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
0.15
-
at pH 7.5 and 37°C Saccharomyces cerevisiae 5-(4-(2-hydroxy-3-(phenylamino)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
0.18
-
at pH 7.5 and 37°C Saccharomyces cerevisiae Polyoxin B
0.36
-
at pH 7.5 and 37°C Saccharomyces cerevisiae 5-(4-(3-((4-chlorophenyl)amino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
0.37
-
at pH 7.5 and 37°C Saccharomyces cerevisiae 5-(4-(3-(butylamino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
0.38
-
at pH 7.5 and 37°C Saccharomyces cerevisiae 5-(4-(3-((4-bromophenyl)amino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
0.47
-
at pH 7.5 and 37°C Saccharomyces cerevisiae 5-(4-(2-hydroxy-3-(1H-imidazol-1-yl)propyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride
0.47
-
at pH 7.5 and 37°C Saccharomyces cerevisiae 5-(4-(3-((2-chlorophenyl)amino)-2-hydroxypropyl)piperazin-1-yl)-2-oxo-1,2,3,4-tetrahydroquinoline hydrochloride