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Literature summary for 2.4.1.16 extracted from

  • Ge, Z.; Ji, Q.; Chen, C.; Liao, Q.; Wu, H.; Liu, X.; Huang, Y.; Yuan, L.; Liao, F.
    Synthesis and biological evaluation of novel 3-substituted amino-4-hydroxylcoumarin derivatives as chitin synthase inhibitors and antifungal agents (2016), J. Enzyme Inhib. Med. Chem., 31, 219-228.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
additional information synthesis and biological evaluation of novel 3-substituted amino-4-hydroxylcoumarin derivatives as chitin synthase inhibitors and antifungal agents, overview. Most of the compounds have good inhibitory activity against CHS, in which the best compound with IC50 of 0.10 mmol/l has stronger activity than that of polyoxin B As far as the antifungal activity is concerned, most of the compounds possessed moderate to excellent activity against some representative pathogenic fungi. The most potent agent against Cryptococcus neoformans has a minimal inhibitory concentration (MIC) of 0.004 mg/ml. The compounds have negligible actions to some tested bacteria and are promising to develop selective antifungal agents Cryptococcus neoformans
Polyoxin B
-
 Cryptococcus neoformans

Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans
-
-
-

Synonyms

Synonyms Comment Organism
CHS
-
 Cryptococcus neoformans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.18
-
 pH and temperature not specified in the publication Cryptococcus neoformans Polyoxin B