Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | synthesis and biological evaluation of novel 3-substituted amino-4-hydroxylcoumarin derivatives as chitin synthase inhibitors and antifungal agents, overview. Most of the compounds have good inhibitory activity against CHS, in which the best compound with IC50 of 0.10 mmol/l has stronger activity than that of polyoxin B As far as the antifungal activity is concerned, most of the compounds possessed moderate to excellent activity against some representative pathogenic fungi. The most potent agent against Cryptococcus neoformans has a minimal inhibitory concentration (MIC) of 0.004 mg/ml. The compounds have negligible actions to some tested bacteria and are promising to develop selective antifungal agents | Cryptococcus neoformans | |
Polyoxin B | - |
Cryptococcus neoformans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptococcus neoformans | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
CHS | - |
Cryptococcus neoformans |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.18 | - |
pH and temperature not specified in the publication | Cryptococcus neoformans | Polyoxin B |