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Literature summary for 2.4.1.16 extracted from

  • Ke, S.; Liu, F.; Wang, N.; Yang, Q.; Qian, X.
    1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation (2009), Bioorg. Med. Chem. Lett., 19, 332-335.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1-(2,2-dibutyl-5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-3(2H)-yl)ethanone 0.25 mM, about 30% residual activity Saccharomyces cerevisiae
1-[2,2-dibutyl-5-(2-chlorophenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone 0.25 mM, about 10% residual activity Saccharomyces cerevisiae
1-[2,2-dibutyl-5-(4-chlorophenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone 0.25 mM, about 30% residual activity Saccharomyces cerevisiae
1-[2,2-dibutyl-N-[(2,6-difluorophenyl)carbonyl]-5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone 0.25 mM, about 20% residual activity Saccharomyces cerevisiae
1-[2,2-dibutyl-N-[(2-chlorophenyl)carbonyl]-5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone 0.25 mM, about 15% residual activity Saccharomyces cerevisiae
1-[2,2-dibutyl-N-[(2-chlorophenyl)carbonyl]-5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone 0.25 mM, about 25% residual activity Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0056
-
-
 Saccharomyces cerevisiae 1-[2,2-dibutyl-N-[(2-chlorophenyl)carbonyl]-5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone
0.0079
-
-
 Saccharomyces cerevisiae 1-[2,2-dibutyl-5-(2-chlorophenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone