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Literature summary for 2.4.1.16 extracted from

  • Broehan, G.; Zimoch, L.; Wessels, A.; Ertas, B.; Merzendorfer, H.
    A chymotrypsin-like serine protease interacts with the chitin synthase from the midgut of the tobacco hornworm (2007), J. Exp. Biol., 210, 3636-3643.
    View publication on PubMed
Search for more literature for 2.4.1.16

Cloned(Commentary)

Cloned (Comment) Organism
cloning from anterior midguts of fifth instar larvae, expression in Saccharomyces cerevisiae AH109 cells and protein interaction analysis by yeast two hybrid screening, identifying a chymotrypsin-like protease CTLP1 that binds to the extracellular carboxyterminal domain of CHS2 Manduca sexta

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane CHS2 with an extracellular C-terminal domain Manduca sexta 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Manduca sexta chitin synthesis is controlled by an intestinal proteolytic signalling cascade linking chitin synthase activity to the nutritional state of the larvae, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Manduca sexta Q530Z6
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-

Source Tissue

Source Tissue Comment Organism Textmining
larva distribution of CTLP1 and CHS2 in cryosections of the anterior midgut from fifth instar larvae, overview Manduca sexta
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midgut chitin is synthesized by columnar cells Manduca sexta
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information chitin synthesis is controlled by an intestinal proteolytic signalling cascade linking chitin synthase activity to the nutritional state of the larvae, overview Manduca sexta ?
-
 ?
additional information CHS2 interacts with the extracellular chymotrypsin-like protease CTLP1 in the midgut, overview Manduca sexta ?
-
 ?

Synonyms

Synonyms Comment Organism
chitin synthase 2
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 Manduca sexta
Chs2
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 Manduca sexta