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Literature summary for 2.4.1.16 extracted from

  • Valdivieso, M.H.; Duran, A.; Roncero, C.
    Chitin synthases in yeast and fungi (1999), EXS, 87, 55-69.
    View publication on PubMed
Search for more literature for 2.4.1.16

Cloned(Commentary)

Cloned (Comment) Organism
-
 Saccharomyces cerevisiae
-
 Aspergillus nidulans
-
 Candida albicans
-
 Ustilago maydis

Inhibitors

Inhibitors Comment Organism Structure
Ni2+ inhibition of chitin synthase 1 and 2, no inhibition of chitin synthase 3 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
chitosome
-
 Saccharomyces cerevisiae 45009
-
plasma membrane
-
 Saccharomyces cerevisiae 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ divalent cation required, chitin synthase 2 shows highest activity with chitin synthase 2 Saccharomyces cerevisiae
Mg2+
-
 Aspergillus nidulans
Mg2+ divalent cation required, chitin synthase 1 and 3 have a preference for Mg2+ Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n Saccharomyces cerevisiae
-
 UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n Aspergillus nidulans chitin synthase 1 is involved in repair functions at the end of cytokinesis, chitin synthase 2 is responsible for the synthesis of the primary septum that separates mother and daughter cells, chitin synthase 3 is responsible for the formation of the ring where most of the cell wall chitin is located UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-
Candida albicans
-
-
-
Rhizopus microsporus var. oligosporus
-
-
-
Saccharomyces cerevisiae
-
 chitin synthase 1, 2 and 3
-
Ustilago maydis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification
-
 Aspergillus nidulans
proteolytic modification
-
 Candida albicans
proteolytic modification several proteases, including trypsin and chymotrypsin activate chitin synthase 1 and 2. Chitin synthase 3 requires the presence of substrate during protease treatment in order to be activated to some extent Saccharomyces cerevisiae

Source Tissue

Source Tissue Comment Organism Textmining
additional information level of chitin synthase 1 remains constant during vegetative growth in synchronised cells Saccharomyces cerevisiae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Saccharomyces cerevisiae UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Aspergillus nidulans UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Candida albicans UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Ustilago maydis UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Rhizopus microsporus var. oligosporus UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n chitin synthase 1 is involved in repair functions at the end of cytokinesis, chitin synthase 2 is responsible for the synthesis of the primary septum that separates mother and daughter cells, chitin synthase 3 is responsible for the formation of the ring where most of the cell wall chitin is located Aspergillus nidulans UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?