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Literature summary for 2.4.1.16 extracted from
- Solubilization and partial purification of yeast chitin synthetase. Confirmation of the zymogenic nature of the enzyme (1978), J. Biol. Chem., 253, 4419-4425.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| lysophosphatidylserine | required, phosphatidylserine and lysophosphatidylserine are the best activators | Saccharomyces cerevisiae |  |
| phosphatidylserine | required, phosphatidylserine and lysophosphatidylserine are the best activators | Saccharomyces cerevisiae | |
| Phospholipid | required, phosphatidylserine and lysophosphatidylserine are the best activators | Saccharomyces cerevisiae | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Polyoxin D | - |
Saccharomyces cerevisiae | |
| UDP | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.5 | - |
UDP-N-acetylglucosamine | - |
Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Saccharomyces cerevisiae | 5886 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus flavus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | enzyme exists as a zymogen | Saccharomyces cerevisiae |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Saccharomyces cerevisiae | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
| UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Aspergillus flavus | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
Polyoxin D | - |
Saccharomyces cerevisiae | |
| 2 | - |
UDP | - |
Saccharomyces cerevisiae | |
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