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Literature summary for 2.4.1.155 extracted from

  • Zhao, Y.; Nakagawa, T.; Itoh, S.; Inamori, K.; Isaji, T.; Kariya, Y.; Kondo, A.; Miyoshi, E.; Miyazaki, K.; Kawasaki, N.; Taniguchi, N.; Gu, J.
    N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migration (2006), J. Biol. Chem., 281, 32122-32130.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
MKN45 cells are transfected with GnT-III, GnT-V, or both, respectively Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R Homo sapiens GnTIII competes with GnT-V for the modification of integrin alpha3 subunit in living cells. This competition results in the inhibition of alpha3beta1 integrin-mediated cell migration induced by GnT-V UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R GnTIII competes with GnT-V for the modification of integrin alpha3 subunit in living cells. This competition results in the inhibition of alpha3beta1 integrin-mediated cell migration induced by GnT-V Homo sapiens UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
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