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Literature summary for 2.4.1.155 extracted from

  • Ito, Y.; Akinaga, A.; Yamanaka, K.; Nakagawa, T.; Kondo, A.; Dickson, R.B.; Lin, C.Y.; Miyauchi, A.; Taniguchi, N.; Miyoshi, E.
    Co-expression of matriptase and N-acetylglucosaminyltransferase V in thyroid cancer tissues - its possible role in prolonged stability in vivo by aberrant glycosylation (2006), Glycobiology, 16, 368-374.
    View publication on PubMed
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Application

Application Comment Organism
medicine prognosis of thyroid carcinoma after surgery is not correlated with the expression GnT-V because the levels of expression is quite low in anaplastic (undifferentiated) carcinomas Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R Homo sapiens catalyzes the formation of beta-1-6 GlcNAc branches on asparagine-linked oligosaccharides, which is directly linked to tumorigenesis UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
anaplastic thyroid cancer cell observed in 6/28 cases Homo sapiens
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follicular thyroid cancer cell oberserved in 10/23 cases Homo sapiens
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additional information not expressed in normal thyroid tissue Homo sapiens
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papillary thyroid cancer cell observed in 66/68 cases Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R catalyzes the formation of beta-1-6 GlcNAc branches on asparagine-linked oligosaccharides, which is directly linked to tumorigenesis Homo sapiens UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
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 ?

Synonyms

Synonyms Comment Organism
GnT-V
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 Homo sapiens
UDP-N-acetylglucosamine:a-mannoside beta-1,6-N-acetylglucosaminyltransferase
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 Homo sapiens