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Literature summary for 2.4.1.152 extracted from

  • Wang, Q.Y.; Zhang, Y.; Shen, Z.H.; Chen, H.L.
    alpha1,3 fucosyltransferase-VII up-regulates the mRNA of alpha5 integrin and its biological function (2008), J. Cell. Biochem., 104, 2078-2090.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
regions 5' of the FUT VI transcription start site, -2,067 to +1 nt and -2,067 to +213 nt isolated, PCR products 5'-phosphorylated using the T4 polynucleotide kinase and then ligated into pGL4.11 vector digested with EcoRV and treated with alkaline phosphatase from Escherichia coli. Plasmids transiently transfected into HepG2 and HuH-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information deletion of the -2,067 to -662 nt region enhances luciferase activity. The FUT VI promoter regions carrying deletions of conserved binding motifs are unaffected by overexpression of Oct-1 via transfection with pcDNA3.2/Oct--1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
alpha1,3-fucosyltransferase VI
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Homo sapiens
fucosyltransferase VI
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Homo sapiens
FUT VI
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens two hepatocyte nuclear factor-4alpha (HNF-4alpha) and one octamer binding transcription factor-1 (Oct-1) binding sites are essential for FUT VI transcription, which are the 5'-flanking regions at positions -156 to -136 nt and -56 to -19 nt relative to the FUT VI gene transcription start site. Transient overexpression of HNF-4alpha but not Oct-1 enhances both FUT VI promoter activities and FUT VI mRNA levels in HuH-7 cells. FUT VI mRNA levels are higher in HepG2 cells than in HNF-4alpha-transfected HuH-7 cells up