Literature summary for 2.4.1.152 extracted from

Hiraoka, N.; Petryniak, B.; Kawashima, H.; Mitoma, J.; Akama, T.O.; Fukuda, M.N.; Lowe, J.B.; Fukuda, M.
Significant decrease in alpha1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing (2007), Glycobiology, 17, 277-293.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in CHO cells, to confirm the hypothesis that FucT-VII and keratin sulfate sulfotransferase (KSST) may compete for the same acceptor molecules FucT-VII and Core2GlcNAcT-1 are expressed in CHO cells stably expressing KSST, sialyl Lewis X expression is significantly reduced in these cells	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	O-linked oligosaccharides attached to GlyCAM-1 are analyzed in FucT-VII deficient mice, an 80% reduction in alpha1,3-fucosylated structures in 6-sulfo sialyl Lewis X and a significant increase in 6-sulfo N-acetyllactosamine are found in high-endothelial venules in secondary lymphoid organs of FucT-VII -/- mice, surprisingly, the amount of 6-sulfated galactose (Gal) is also increased in mutant mice, since 6-sulfo galactose can be synthesized by keratin sulfate sulfotransferase (KSST) it could be concluded that FucT-VII and KSST may compete for the same acceptor molecules	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
fucosyltransferase-VII	-	Mus musculus
FucT-VII	-	Mus musculus

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Release 2023.1 (January 2023)