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Literature summary for 2.4.1.152 extracted from
- Cloning and expression of rat fucosyltransferase VII at sites of inflammation (2005), Apmis, 113, 613-620.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cloning of rat Fuc-TVII gene which is expressed as two splice variants, but only the long one shows enzymatic activity, expression of the long splice variant in COS-7 cells | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tunicamycin | inhibits N-glycosylation of the enzyme in recombinant COS-7 cells which leads to inactivation of rFuc-TVII | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q712G6 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | Tyr191 of rFuc-TVII is predicted to be O-glycosylated, three potential N-glycosylation sites at residues 86, 109, and 299, N-glycosylation is necessary for enzymatic activity | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | rFuc-TVII mRNA expression undetectable in kidney but it is strongly enhanced during acute inflammatory reaction induced by kidney allograft rejection | Rattus norvegicus | - |
| lymph node | rFuc-TVII mRNA expression strongly detected in rat lymph node | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000017 | - |
substrate sialyl-N-acetyllactosamine | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GDP-L-fucose + sialyl-alpha-2,3-N-acetyllactosamine | - |
Rattus norvegicus | GDP + NeuNAcalpha2-3Galbeta1-4[Fucalpha1-3]GlcNAc | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| rat fucosyltransferase VII | - |
Rattus norvegicus |
| rFuc-TVII | - |
Rattus norvegicus |
| rFUT7 | - |
Rattus norvegicus |
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