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Literature summary for 2.4.1.150 extracted from

  • Fukuda, M.
    beta6-N-acetylglucosaminyltransferase (IGnT) (2002), Handbook of Glycosyltransferases and Related Genes, 2002, 125-132.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
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Mus musculus
cDNA encoding IGnT is cloned from PA-1 cells, 400-amino acids protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane type II transmembrane topology Mus musculus 16020
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membrane type II transmembrane topology Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens expression of I-antigen is entirely dependent on IGnT, expression of IGnT is developmentally regulated ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
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Rattus norvegicus
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-
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Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
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Sus scrofa
cIGnT, purified from PA-1 cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain IGnT is highly expressed in adult cerebellum and the frontal lobe of adult brain, also expression in fetal brain Homo sapiens
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cerebellum IGnT is highly expressed in adult cerebellum Homo sapiens
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colon IGnT is moderately expressed in adult colon Homo sapiens
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gastric mucosa dIGnT Sus scrofa
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heart IGnT is moderately expressed in adult heart Homo sapiens
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kidney
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Mus musculus
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kidney IGnT expression in fetal kidney Homo sapiens
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liver
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Mus musculus
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liver cIGnT Rattus norvegicus
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lung IGnT expression in fetal lung Homo sapiens
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PA-1 cell tetracarcinoma cells, IGnT mainly acts as cIGnT, but can also act as dIGnT with 6-30% of the activity of cIGnT Homo sapiens
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prostate gland IGnT is highly expressed in adult prostata Homo sapiens
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small intestine IGnT is moderately expressed in adult small intestine Homo sapiens
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small intestine cIGnT is the dominant form Sus scrofa
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
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Mus musculus ?
-
?
additional information 2 types of branching enzyme activities: cIGnT6 generates beta-1,6-N-acetylglucosaminyl branches at the central galactose residue, and dIGnT6 acts on peridistal galactose residues Homo sapiens ?
-
?
additional information 2 types of branching enzyme activities: cIGnT6 generates beta-1,6-N-acetylglucosaminyl branches at the central galactose residue, and dIGnT6 acts on peridistal galactose residues Sus scrofa ?
-
?
additional information expression of I-antigen is entirely dependent on IGnT, expression of IGnT is developmentally regulated Homo sapiens ?
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-3)Galbeta(1-3)GalNAcalpha1-R dIGnT Sus scrofa UDP + GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-3)GalNAcalpha1-R
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-3)Galbeta(1-4)Glc dIGnT Sus scrofa UDP + GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-4)Glc
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-3)Galbeta(1-4)Glc(NAc)beta1-R dIGnT Sus scrofa UDP + GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-4)Glc(NAc)beta1-R
-
?
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine
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Mus musculus ?
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?
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine
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Sus scrofa ?
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?
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine transfer of GlcNAc to beta1,4-linked Gal residue in a linear poly-N-acetyllactosamine with the approximate structure Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc(NAc)-R, forming Galbeta(1-4)GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-4)Glc(NAc)-R Homo sapiens ?
-
?