Literature summary for 2.4.1.15 extracted from

Pan, Y.T.; Elbein, A.D.
Inhibition of the trehalose-P synthase of mycobacteria by various antibiotics (1996), Arch. Biochem. Biophys., 335, 258-266.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cathomycin	competitive inhibition, inhibits reaction with either UDPglucose or GDPglucose as glucosyl donor. Preincubation with heparin prevents inhibition. 0.05 mg/ml-0.2 mg/ml: 50% inhibition	Mycolicibacterium smegmatis
circulin	noncompetitive inhibition, inhibits reaction with either UDPglucose or GDPglucose as glucosyl donor. Preincubation with heparin prevents inhibition. 0.05 mg/ml-0.2 mg/ml: 50% inhibition	Mycolicibacterium smegmatis
Diumycin	competitive inhibition, inhibits reaction with either UDPglucose or GDPglucose as glucosyl donor. Preincubation with heparin prevents inhibition. 0.05 mg/ml: 50% inhibition	Mycolicibacterium smegmatis
Moenomycin	competitive inhibition, inhibits reaction with either UDPglucose or GDPglucose as glucosyl donor. Preincubation with heparin prevents inhibition. Preincubation with heparin prevents inhibition. 0.05 mg/ml: 50% inhibition	Mycolicibacterium smegmatis

Organism

Organism	UniProt	Comment	Textmining
Mycolicibacterium smegmatis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-glucose + D-glucose 6-phosphate	-	Mycolicibacterium smegmatis	trehalose 6-phosphate + GDP	-	?
UDPglucose + glucose 6-phosphate	-	Mycolicibacterium smegmatis	trehalose 6-phosphate + UDP	-	?

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Release 2023.1 (January 2023)