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Literature summary for 2.4.1.149 extracted from

  • Gao, L.; Zhang, H.; Zhang, B.; Zhu, J.; Chen, C.; Liu, W.
    B3GNT3 overexpression is associated with unfavourable survival in non-small cell lung cancer (2018), J. Clin. Pathol., 71, 642-647 .
    View publication on PubMed
Search for more literature for 2.4.1.149

Application

Application Comment Organism
diagnostics high expression of B3GNT3 is associated with unfavourable disease-free survival and overall survival in NSCLC patients, suggesting that B3GNT3 might be a potential prognostic biomarker for non-small cell lung cancer (NSCLC). B3GNT3 expression is an independent prognostic factor Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene B3GNT3, real-time PCR enzyme expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R Homo sapiens
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 UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y2A9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
non-small cell lung cancer cell NSCLC, quantitative real-time PCR enzyme expression analysis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R
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 Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R
-
 ?

Synonyms

Synonyms Comment Organism
B3GNT3
-
 Homo sapiens
beta-1,3-N-acetylglucosaminyltransferase-3
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 Homo sapiens

General Information

General Information Comment Organism
physiological function in the 176 non-small cell lung cancer (NSCLC) cases, a high B3GNT3 expression level is positively correlated with lymph node metastasis and advanced TNM (tumor, node, metastasis) stage. Kaplan-Meier analysis indicates that patients with high B3GNT3 expression have significantly lower disease-free survival and overall survival than those with low B3GNT3 expression. B3GNT3 expression is an independent prognostic factor Homo sapiens