Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.149 extracted from

  • Bao, X.; Kobayashi, M.; Hatakeyama, S.; Angata, K.; Gullberg, D.; Nakayama, J.; Fukuda, M.; Fukuda, M.
    Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase (2009), Proc. Natl. Acad. Sci. USA, 106, 12109-12114.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.149

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
MDA-MB-435 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
PC-3H cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetylglucosamine + N-acetyllactosamine
-
 Homo sapiens UDP + GlcNAcbeta(1-3)Galbeta(1-4)GlcNAc
-
 ?

Synonyms

Synonyms Comment Organism
beta3-N-acetylglucosaminyltransferase 1
-
 Homo sapiens
beta3GnT1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the decrease of laminin-binding glycans and consequent increased cell migration are associated with the decreased expression of beta3-N-acetylglucosaminyltransferase-1 down
Homo sapiens forced expression of beta3GnT1 in aggressive cancer cells restores the laminin-binding glycans and decreased tumor formation up

General Information

General Information Comment Organism
physiological function beta3GnT1 is required for laminin-binding glycan synthesis through formation of a complex with LARGE, thus regulating the function of LARGE Homo sapiens