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Literature summary for 2.4.1.149 extracted from

  • Hosomi, O.; Takeya, A.; Kogure, T.
    Human serum contains N-acetyllactosamine: beta 1-3 N-acetylglucosaminyltransferase activity (1984), J. Biochem., 95, 1655-1659.
    View publication on PubMed
Search for more literature for 2.4.1.149

Activating Compound

Activating Compound Comment Organism Structure
ATP omitting ATP from reaction mixture decreases activity by 87% Homo sapiens
additional information not activated by Triton X-100 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.133
-
 UDP-N-acetyl-D-glucosamine lactose as acceptor Homo sapiens
7
-
 N-acetyllactosamine
-
 Homo sapiens
29.8
-
 lactose
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ essential for activity, neither Mg2+ nor Ca2+ can substitute for Mn2+ Homo sapiens
additional information not activated by Mg2+ or Ca2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R Homo sapiens involved in the biosynthesis of blood group precursors, enzyme might control the biosynthesis of the linear carbohydrate chain by adding a N-acetylglucosaminyl residue to a Galbeta(1-4)GlcNAc-R structure present on oligosaccharides, glycosylceramides and glycoproteins UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum normal blood group 0 serum Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no acceptors: melibiose, gentiobiose, galactose, glucose, N-acetylgalactosamine, N-acetylglucosamine Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R
-
 Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R involved in the biosynthesis of blood group precursors, enzyme might control the biosynthesis of the linear carbohydrate chain by adding a N-acetylglucosaminyl residue to a Galbeta(1-4)GlcNAc-R structure present on oligosaccharides, glycosylceramides and glycoproteins Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R
-
 ?
UDP-N-acetylglucosamine + lactose less effective acceptor than N-acetyllactosamine Homo sapiens UDP + GlcNAcbeta(1-3)Galbeta(1-4)Glc
-
 ?
UDP-N-acetylglucosamine + N-acetyllactosamine more effective acceptor than lactose Homo sapiens UDP + GlcNAcbeta(1-3)Galbeta(1-4)GlcNAc
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens