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Literature summary for 2.4.1.146 extracted from

  • Brockhausen, I.; Kuhns, W.; Schachter, H.; Matta K.L.; Sutherland, D.R.; Baker, M.A.
    Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Galbeta3GalNAcalpha-R (GlcNAc to GalNAc) beta(1,6)-N-acetylglucosaminyltransferase in leikemic cells (1991), Cancer Res., 51, 1257-1263.
    View publication on PubMed
Search for more literature for 2.4.1.146

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ not required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
granulocyte low level, in normal, but not in leukemic cells Homo sapiens
-
additional information not detectable in acute myeloid leukemia blast cell line and chronic myelogenous leukemia granulocyte cell line Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000006
-
 normal granulocytes Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R elongation Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R i.e. core class 1 Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R enzyme competes with core 2 beta6-GlcNAc transferase, EC 2.4.1.102, for same substrates Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?

Synonyms

Synonyms Comment Organism
elongation 3beta-GalNAc transferase
-
 Homo sapiens
elongation beta3 Gn-T
-
 Homo sapiens