Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.144 extracted from

  • Xu, Q.; Isaji, T.; Lu, Y.; Gu, W.; Kondo, M.; Fukuda, T.; Du, Y.; Gu, J.
    Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines (2012), J. Biol. Chem., 287, 16563-16574.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.144

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
 x * 52000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE Mus musculus
52000
-
 x * 52000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE Homo sapiens
62000
-
 x * 62000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE Mus musculus
62000
-
 x * 62000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
GE-11 cell
-
 Mus musculus
-
MCF-10A cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manbeta(1->3)Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-NH(CH2)4NH(2-pyridyl)
-
 Mus musculus ?
-
 ?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manbeta(1->3)Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-NH(CH2)4NH(2-pyridyl)
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 52000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE Mus musculus
? x * 52000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE Homo sapiens
? x * 62000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE Mus musculus
? x * 62000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
GnT-III
-
 Mus musculus
GnT-III
-
 Homo sapiens
N-acetylglucosaminyltransferase III
-
 Mus musculus
N-acetylglucosaminyltransferase III
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus the expression levels of GnT-III are suppressed about 25fold in transforming growth factor-beta-treated cells (5 ng/ml) down
Homo sapiens the expression levels of GnT-III are suppressed about 25fold in transforming growth factor-beta-treated cells (5 ng/ml) down

General Information

General Information Comment Organism
physiological function the enzyme plays an important role in the suppression of cancer metastasis. The enzyme influences epithelial-to-mesenchymal transition-like changes through not only prolongation of E-cadherin turnover but also suppression of beta-catenin-p-Smad complex formation. The enzyme plays important roles in transforming growth factor-beta-induced epithelial-to-mesenchymal transition-like changes. The enzyme does not significantly affect the expression of E-cadherin mRNA Mus musculus
physiological function the enzyme plays an important role in the suppression of cancer metastasis. The enzyme influences epithelial-to-mesenchymal transition-like changes through not only prolongation of E-cadherin turnover but also suppression of beta-catenin-p-Smad complex formation. The enzyme plays important roles in transforming growth factor-beta-induced epithelial-to-mesenchymal transition-like changes. The enzyme does not significantly affect the expression of E-cadherin mRNA Homo sapiens