Cloned (Comment) | Organism |
---|---|
gene MGAT3, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | GnT-III overexpression does not affect cell morphology. Gastric cells overexpressing GnT-III appears to exhibit a more focused immunolocalization at cell-cell borders than control cells. In GnT-III transfected cells there is a well-localized continuous staining of E-cadherin at the cell membrane that correlates with F-actin staining, suggesting co-localization, GnT-III overexpression prevents clathrin-dependent E-cadherin endocytosis, phenotype, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R | Homo sapiens | - |
UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q09327 | gene MGAT3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Homo sapiens | - |
gastric carcinoma cell | - |
Homo sapiens | - |
MKN-45 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R | - |
Homo sapiens | UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GnT-III | - |
Homo sapiens |
N-acetylglucosaminyltransferase III | - |
Homo sapiens |
N-acetylglucosaminyltransferase-III | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | existence of a bi-directional cross-talk between E-cadherin and two major N-glycan processing enzymes, N-acetylglucosaminyltransferase-III or -V (GnT-III or GnT-V). Molecular mechanisms underlying E-cadherin regulation in gastric cancer, overview | Homo sapiens |
additional information | GnT-III overexpression does not affect cell morphology | Homo sapiens |
physiological function | the enzyme induces a stabilizing effect on E-cadherin at the cell membrane by inducing a delay in the turnover rate of the protein, contributing for the formation of stable and functional adherens-junctions, and further preventing clathrin-dependent E-cadherin endocytosis. The enzyme plays a role on E-cadherin-mediated tumor suppression | Homo sapiens |
physiological function | GnT-III induced a stabilizing effect on E-cadherin at the cell membrane by inducing a delay in the turnover rate of the protein, contributing for the formation of stable and functional adherens-junctions, and further preventing clathrin-dependent E-cadherin endocytosis. Role of GnT-III on E-cadherin-mediated tumor suppression. GnT-III catalyzes the formation of a bisecting GlcNAc structure in N-glycans and is a metastases suppressor. E-cadherin is specifically modified with bisecting GlcNAc or beta1,6 GlcNAc branched structures | Homo sapiens |