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Literature summary for 2.4.1.144 extracted from

  • Zhao, Y.; Nakagawa, T.; Itoh, S.; Inamori, K.; Isaji, T.; Kariya, Y.; Kondo, A.; Miyoshi, E.; Miyazaki, K.; Kawasaki, N.; Taniguchi, N.; Gu, J.
    N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migration (2006), J. Biol. Chem., 281, 32122-32130.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R Homo sapiens GnT-III catalyzes the formation of a bisecting GlcNAc structure in N-glycans, resulting in the suppression of metastasis. The priority of GnT-III for the modification of the integrin alpha3 subunit may be an explanation for why GnT-III inhibits GnT-V-induced cell migration. TGnT-III and GnT-V can competitively modify the same target glycoprotein and furthermore positively or negatively regulate its biological functions UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
CHP-134 cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R GnT-III catalyzes the formation of a bisecting GlcNAc structure in N-glycans, resulting in the suppression of metastasis. The priority of GnT-III for the modification of the integrin alpha3 subunit may be an explanation for why GnT-III inhibits GnT-V-induced cell migration. TGnT-III and GnT-V can competitively modify the same target glycoprotein and furthermore positively or negatively regulate its biological functions Homo sapiens UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R
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Synonyms

Synonyms Comment Organism
GnT-III
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Homo sapiens
N-acetylglucosaminyltransferase III
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Homo sapiens