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Literature summary for 2.4.1.144 extracted from

  • Rouwendal, G.J.; Wuhrer, M.; Florack, D.E.; Koeleman, C.A.; Deelder, A.M.; Bakker, H.; Stoopen, G.M.; van Die, I.; Helsper, J.P.; Hokke, C.H.; Bosch, D.
    Efficient introduction of a bisecting GlcNAc residue in tobacco N-glycans by expression of the gene encoding human N-acetylglucosaminyltransferase III (2007), Glycobiology, 17, 334-344.
    View publication on PubMed
Search for more literature for 2.4.1.144

Application

Application Comment Organism
medicine the majority of N-glycans of a recombinant antibody produced in Nicotiana tabacum expressing GnT-III is bisected and devoid of paucimannosidic structures. This might improve the efficacy of therapeutic antibodies produced in the transgenic plants Homo sapiens
synthesis introduction of human N-acetylglucosaminyltransferase gene into tobacco plants leads to highly efficient synthesis of bisected N-glycans. The majority of N-glycans of an antibody produced in a plant expressing GnT-III is also bisected. This might improve the efficacy of therapeutic antibodies produced in this type of transgenic plant Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
introduction of human N-acetylglucosaminyltransferase (GnT)-III gene into Nicotiana tabacum leads to highly efficient synthesis of bisected N-glycans Homo sapiens
introduction of human N-acetylglucosaminyltransferase gene into tobacco plants leads to highly efficient synthesis of bisected N-glycans. The majority of N-glycans of an antibody produced in a plant expressing GnT-III is also bisected. This might improve the efficacy of therapeutic antibodies produced in this type of transgenic plant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
(GnT)-III
-
 Homo sapiens
N-acetylglucosaminyltransferase III
-
 Homo sapiens