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Literature summary for 2.4.1.138 extracted from

  • Lopez-Avalos, M.D.; Uccelletti, D.; Abeijon, C.; Hirschberg, C.B.
    The UDPase activity of the Kluyveromyces lactis Golgi GDPase has a role in uridine nucleotide sugar transport into Golgi vesicles (2001), Glycobiology, 11, 413-422.
    View publication on PubMed
Search for more literature for 2.4.1.138

Protein Variants

Protein Variants Comment Organism
additional information enzyme activity in KL8 null mutant, which has no remaining UDPase activity, is reduced due to lack of UDP-N-acetyl-D-glucosaminose Kluyveromyces lactis

Inhibitors

Inhibitors Comment Organism Structure
UDP
-
 Kluyveromyces lactis

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi membrane catalytic reaction takes place in the lumen of Golgi vesicles Kluyveromyces lactis 139
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose Kluyveromyces lactis involved in biosynthesis of mannoprotein side-chain units UDP + 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose
-
 ?
UDP-N-acetyl-D-glucosamine + 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose Kluyveromyces lactis KL8 involved in biosynthesis of mannoprotein side-chain units UDP + 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose
-
 ?

Organism

Organism UniProt Comment Textmining
Kluyveromyces lactis
-
-
-
Kluyveromyces lactis KL8
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme depends on the UDPase, which generates UDP as antiporter to transport UDP-N-acetyl-D-glucosamine into the Golgi lumen Kluyveromyces lactis ?
-
 ?
additional information enzyme depends on the UDPase, which generates UDP as antiporter to transport UDP-N-acetyl-D-glucosamine into the Golgi lumen Kluyveromyces lactis KL8 ?
-
 ?
UDP-N-acetyl-D-glucosamine + 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose
-
 Kluyveromyces lactis UDP + 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose
-
 ?
UDP-N-acetyl-D-glucosamine + 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose involved in biosynthesis of mannoprotein side-chain units Kluyveromyces lactis UDP + 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose
-
 ?
UDP-N-acetyl-D-glucosamine + 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose
-
 Kluyveromyces lactis KL8 UDP + 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose
-
 ?
UDP-N-acetyl-D-glucosamine + 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose involved in biosynthesis of mannoprotein side-chain units Kluyveromyces lactis KL8 UDP + 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose
-
 ?