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Literature summary for 2.4.1.135 extracted from

  • Gogate, S.S.; Nasser, R.; Shapiro, I.M.; Risbud, M.V.
    Hypoxic regulation of beta-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins (2011), Arthritis Rheum., 63, 1950-1960.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte
-
 Rattus norvegicus
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N-1511 cell
-
 Rattus norvegicus
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nucleus pulposus
-
 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
beta-1,3-glucuronyltransferase 1
-
 Rattus norvegicus
GlcAT-1
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus under hypoxic conditions (1% O2) there is an increase in enzyme expression both in nucleus pulposus cells and in N1511 chondrocytes. Suppression of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha induces enzyme promoter activity and expression only in nucleus pulposus cells up