Cloned (Comment) | Organism |
---|---|
expression of full-length GlcAT-I in COS-1 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0293 | - |
UDPglucuronate | - |
Homo sapiens | |
0.0804 | - |
Galbeta(1-3)Galbeta(1-4)Xyl | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | divalent cations essential, 2.7% as effective as Mn2+ | Homo sapiens | |
Mg2+ | divalent cations essential, 5.5% as effective as Mn2+ | Homo sapiens | |
Mn2+ | divalent cations essential, Mn2+ exhibits highest activity, optimal concentration: 2 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans | ? | - |
? | |
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl | Homo sapiens | high expression of the GlcAT-I gene renders the cells capable of synthesizing the HNK-1 epitope | UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | negligible activity with Galbeta(1-3)galbeta1-O-benzyl, galbeta(1-4)GlcNAc and galbeta(1-4)Glc | Homo sapiens | ? | - |
? | |
additional information | the enzyme is involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans | Homo sapiens | ? | - |
? | |
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl | - |
Homo sapiens | UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl | - |
? | |
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl | high expression of the GlcAT-I gene renders the cells capable of synthesizing the HNK-1 epitope | Homo sapiens | UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
- |
Homo sapiens |