Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.133 extracted from

  • Wei, Y.; Liu, D.; Zhou, F.; Ge, Y.; Xu, J.; Yun, X.; Gu, J.; Jiang, J.
    Identification of beta-1,4-galactosyltransferase I as a target gene of HBx-induced cell cycle progression of hepatoma cell (2008), J. Hepatol., 49, 1029-1037.
    View publication on PubMed
Search for more literature for 2.4.1.133

Protein Variants

Protein Variants Comment Organism
Y306G/W307G double-mutant deprives the galactosyltransferase activity of GalT I, the point mutation abolishes the ability of GalT I to promote cell cycle progression of hepatoma cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens beta-1,4-galactosyltransferase is responsible for the biosynthesis of Gal-beta - 4GlcNAc units in N-glycans and core 2 O-glycans of glycoproteins, including IgG, gp120 and serum alpha-fetoprotein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15291
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information beta-1,4-galactosyltransferase is responsible for the biosynthesis of Gal-beta - 4GlcNAc units in N-glycans and core 2 O-glycans of glycoproteins, including IgG, gp120 and serum alpha-fetoprotein Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
beta-1,4-galactosyltransferase I
-
 Homo sapiens
GalT I
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens decreasing of the expression of GalT I in hepatoma cells reduce the ability of tumor formation in vivo and inhibits hepatitis B virus-encoded protein HBx-induced cell cycle progression additional information
Homo sapiens GalT I is highly expressed in hepatocellular carcinoma and transcriptionally up-regulated by hepatitis B virus-encoded HBx, and functions as a positive growth regulator in hepatoma cells up

General Information

General Information Comment Organism
physiological function GalT I acts as a positive growth regulator in hepatoma cells depending on its galactosylation activity Homo sapiens