Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.129 extracted from

  • Bandara, A.; Schurig, G.; Sriranganathan, N.; Prasad, R.; Boyle, S.
    The putative penicillin-binding proteins 1 and 2 are important for viability, growth and cell morphology of Brucella melitensis (2009), Vet. Microbiol., 133, 387-393.
    View publication on PubMed
Search for more literature for 2.4.1.129

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Top10 cells Brucella melitensis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm isoforms PBP-1A, PBP-1B, and PBP-2 Brucella melitensis 5737
-
periplasmic space isoform PBP-1C Brucella melitensis 42597
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol Brucella melitensis
-
 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Brucella melitensis
-
 strains 16 M and 16 MDELTApbp1C
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Brucella melitensis [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PBP-1A isoform Brucella melitensis
PBP-1B isoform Brucella melitensis
PBP-1C isoform Brucella melitensis
PBP-2 isoform Brucella melitensis
penicillin-binding protein
-
 Brucella melitensis

General Information

General Information Comment Organism
physiological function pbp-1C gene regulates in vitro growth and cell morphology, whereas pbp-1A, pbp-1B, and pbp-2 genes are essential for viability of Brucella melitensis Brucella melitensis