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Literature summary for 2.4.1.11 extracted from

  • Pugazhenthi, S.; Khandelwal, R.L.
    Regulation of glycogen synthase activation in isolated hepatocytes (1995), Mol. Cell. Biochem., 149-150, 95-101.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
aspartate increased uptake leads to activation Mammalia
D-glucose
-
Mammalia
D-glucose
-
Rattus norvegicus
dihydroxyacetone increase of activity Mammalia
fructose increase of activity Mammalia
galactose increase of activity Mammalia
glutamate increased uptake leads to activation Mammalia
Insulin
-
Rattus norvegicus
Insulin inhibits phosphorylation by kinases and synthase phospatase Mammalia
mannose increase of activity Mammalia
proline increased uptake leads to activation Mammalia
propionate significant activation Ovis aries
staurosporine
-
Mammalia
xylitol increase of activity Mammalia

Inhibitors

Inhibitors Comment Organism Structure
CaCl2
-
Mammalia
calyculin A
-
Mammalia
Cl-
-
Mammalia
epinephrine leads to phosphorylation of enzyme Mammalia
glucagon leads to phosphorylation of enzyme Mammalia
microcystin
-
Mammalia
okadaic acid
-
Mammalia
Oxytocin leads to phosphorylation of enzyme Rattus norvegicus
Phorbol esters
-
Mammalia
Vasopressin leads to phosphorylation of enzyme Mammalia

Metals/Ions

Metals/Ions Comment Organism Structure
Li+
-
Mammalia
additional information
-
Oryctolagus cuniculus
additional information regulation of enzyme activity Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + glycogen Mammalia
-
glycogen + UDP
-
?
UDP-glucose + glycogen Rattus norvegicus
-
glycogen + UDP
-
?
UDP-glucose + glycogen Oryctolagus cuniculus
-
glycogen + UDP
-
?
UDP-glucose + glycogen Ovis aries
-
glycogen + UDP
-
?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-
Oryctolagus cuniculus
-
-
-
Ovis aries
-
sheep
-
Rattus norvegicus
-
diabetic rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
Rattus norvegicus
phosphoprotein phosphorylation of glucose-6-phosphate independent enzyme, i.e. I enzyme, results in glucose-6-phosphate dependent enzyme, i.e. D enzyme Mammalia
phosphoprotein phosphorylation of glucose-6-phosphate independent enzyme, i.e. I enzyme, results in glucose-6-phosphate dependent enzyme, i.e. D enzyme Oryctolagus cuniculus
phosphoprotein multiple phosphorylations on serine residues leads to inactivation Mammalia
phosphoprotein phosphorylation at more than 10 sites Oryctolagus cuniculus
phosphoprotein phosphorylation leads to loss of activity Mammalia
phosphoprotein phosphorylation leads to loss of activity Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Rattus norvegicus
-
hepatocyte
-
Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + glycogen
-
Mammalia glycogen + UDP
-
?
UDP-glucose + glycogen
-
Rattus norvegicus glycogen + UDP
-
?
UDP-glucose + glycogen
-
Oryctolagus cuniculus glycogen + UDP
-
?
UDP-glucose + glycogen
-
Ovis aries glycogen + UDP
-
?

Subunits

Subunits Comment Organism
?
-
Rattus norvegicus
?
-
Oryctolagus cuniculus
? x * 80000-93000 Mammalia