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Literature summary for 2.4.1.11 extracted from

  • Killilea, S.D.; Whelan, W.J.
    Purification and properties of rabbit-liver glycogen synthase (1976), Biochemistry, 15, 1349-1356.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
glucose 6-phosphate synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa Oryctolagus cuniculus

General Stability

General Stability Organism
freezing leads to loss of activity Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
beta-Glycerophosphate
-
Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
2 * 85000, SDS-PAGE Oryctolagus cuniculus
170000
-
synthase I, sucrose density gradient centrifugation Oryctolagus cuniculus
183000
-
synthase D, sucrose density gradient centrifugation Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + glycogen Oryctolagus cuniculus
-
glycogen + UDP
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein incorporation of 1.13 mol phosphate per subunit Oryctolagus cuniculus
phosphoprotein phosphorylation leads to loss of activity Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
25
-
-
Oryctolagus cuniculus

Storage Stability

Storage Stability Organism
-70°C, beta-glycerophosphate buffer, 1 year Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + glycogen
-
Oryctolagus cuniculus glycogen + UDP
-
?

Subunits

Subunits Comment Organism
dimer 2 * 85000, SDS-PAGE Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Oryctolagus cuniculus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
25
-
stable in imidazole or beta-glycerophosphate buffer, instable in Tris or glycylglycine buffer Oryctolagus cuniculus