Literature summary for 2.4.1.102 extracted from

Kojima, Y.; Yoneyama, T.; Hatakeyama, S.; Mikami, J.; Sato, T.; Mori, K.; Hashimoto, Y.; Koie, T.; Ohyama, C.; Fukuda, M.; Tobisawa, Y.
Detection of core2 beta-1,6-N-acetylglucosaminyltransferase in post-digital rectal examination urine is a reliable indicator for extracapsular extension of prostate cancer (2015), PLoS ONE, 10, e0138520.

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Application

Application	Comment	Organism
diagnostics	detection of core2 beta-1,6-N-acetylglucosaminyltransferase in post-digital rectal examination urine is a reliable indicator for extracapsular extension of prostate cancer. The number of GCNT1-positive cases is significantly lower in cases of organ-confined disease than in cases of extracapsular extension. GCNT1-negative tumors are a associated with significantly better prostate-specific antigen (PSA)-free survival compared with GCNT1-positive tumors. Multivariate analysis reveals that detection of GCNT1 expression is an independent risk factor for prostate-specific antigen recurrence	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
prostate cancer cell	GCNT1 immunohistochemic analysis, overview. The anti-GCNT1 monoclonal antibody shows high specificity against human GCNT1	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
core2 beta-1,6-N-acetylglucosaminyltransferase	-	Homo sapiens
core2 beta-1,6-N-acetylglucosaminyltransferase-1	-	Homo sapiens
GCNT1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	enzyme GCNT1 expression in prostate cancer specimens from radical prostatectomy correlates with prostate cancer aggressiveness	Homo sapiens

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Release 2023.1 (January 2023)