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Literature summary for 2.4.1.102 extracted from

  • Cabrera, P.V.; Amano, M.; Mitoma, J.; Chan, J.; Said, J.; Fukuda, M.; Baum, L.G.
    Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death (2006), Blood, 108, 2399-2406.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
HH and BW5147 cells are transfected with either wild-type or mutant human C2GnT-I cDNA. Expression of C2GnT-I makes HH cells susceptible to galectin-1 Mus musculus

Protein Variants

Protein Variants Comment Organism
S158C mutation reduces C2GnT activity but does not affect substrate specificity or enzyme dimerization. Mutation appears to result in haploinsufficiency of C2GnT activity. C2GnT-I haploinsufficiency is sufficient for loss of core 2 O-glycan expression and galectin-1 resistance Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death Mus musculus ?
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 ?
UDP-N-acetyl-D-glucosamine + Galbeta1,3GalNAc-O-p-nitrophenyl
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 Mus musculus ?
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 ?