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Literature summary for 2.4.1.102 extracted from

  • Prorok-Hamon, M.; Notel, F.; Mathieu, S.; Langlet, C.; Fukuda, M.; El-Battari, A.
    N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin (2005), Biochem. J., 391, 491-502.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine good drug targets for the treatment of inflammatory disorders and other pathologies involving selectins Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
wild-type and mutant enzymes expressed in CHO-K1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
T60A about 65% of the wild-type in vitro activity, mutation results in a significant increase in electrophoretic mobilities of the protein Homo sapiens
T60A/T97A about 6% of the wild-type in vitro activity, mutant loses the ability of branching P-selectin glycoprotein ligand-1 O-glycans Homo sapiens
T97A about 25% of the wild-type in vitro activity, mutation results in a significant increase in electrophoretic mobilities of the protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens key enzyme for the biosynthesis of sialyl-Lewis x determinants on selectin ligands ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein for C2GnT-I, the N-glycan chain linked to Asn-95 significantly contributes to the synthesis of functional P-selectin glycoprotein ligand-1 and is required to localize the enzyme to the cis/medial-Golgi compartment Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information key enzyme for the biosynthesis of sialyl-Lewis x determinants on selectin ligands Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + Galbeta1,3GalNAc-O-p-nitrophenyl
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
C2GnT-I
-
 Homo sapiens
core2 beta(1,6)-N-acetyglucosaminyltransferase-I
-
 Homo sapiens