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Literature summary for 2.4.1.101 extracted from

  • Schachter, H.
    Mgat1-dependent N-glycans are essential for the normal development of both vertebrate and invertebrate metazoans (2010), Semin. Cell Dev. Biol., 21, 609-615.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Drosophila melanogaster
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + Manalpha(1-3)Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
Drosophila melanogaster UDP + Manalpha(1-3)Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
?
UDP-N-acetyl-D-glucosamine + Manalpha(1-3)Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
Mus musculus UDP + Manalpha(1-3)Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
?
UDP-N-acetyl-D-glucosamine + Manalpha(1-3)Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
Caenorhabditis elegans UDP + Manalpha(1-3)Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
?
UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
Drosophila melanogaster UDP + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
?
UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
Mus musculus UDP + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
?
UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
Caenorhabditis elegans UDP + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
?
UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
Drosophila melanogaster UDP + Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
?
UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
Mus musculus UDP + Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
?
UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
Caenorhabditis elegans UDP + Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
?

Synonyms

Synonyms Comment Organism
gly-12
-
Caenorhabditis elegans
GLY-13
-
Caenorhabditis elegans
gly-14
-
Caenorhabditis elegans
GnTI
-
Drosophila melanogaster
GnTI
-
Mus musculus
GnTI
-
Caenorhabditis elegans
MGAT1
-
Drosophila melanogaster
MGAT1
-
Mus musculus
MGAT1
-
Caenorhabditis elegans
UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I
-
Drosophila melanogaster
UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I
-
Mus musculus
UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I
-
Caenorhabditis elegans

General Information

General Information Comment Organism
malfunction Mgat1-null flies are viable but exhibit pronounced defects in locomotion. Neuron-specific RNAi knockdown of Mgat1 in wild-type flies results in locomotory defects, reduced life span, and about 50% reduction in enzyme activity Drosophila melanogaster
malfunction Mgat1-null mouse embryos die at 9.5-10.5 days after fertilization Mus musculus
malfunction worms with either deletion or RNA-mediated down-regulation of the gly-14 gene are completely resistant to killing by bacteria on PGS medium Caenorhabditis elegans
physiological function Mgat1-dependent N-glycans are required for normal development Drosophila melanogaster
physiological function Mgat1-dependent N-glycans are required for normal development Mus musculus
physiological function Mgat1-dependent N-glycans are required for normal development Caenorhabditis elegans