Crystallization (Comment) | Organism |
---|---|
enzyme in complex with different inhibitory N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)urea compounds, X-ray diffraction structure determination and analysis at 1.8 A resolution, molecular modelling | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione | - |
Oryctolagus cuniculus | |
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one | - |
Oryctolagus cuniculus | |
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione | - |
Oryctolagus cuniculus | |
additional information | N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase, synthesis and evaluation by kinetic and crystallographic data, NMR structure analysis, molecular docking and modelling, overview. N-(trifluoroacetyl)-alpha-D-glucopyranosylamine and N-(trifluoroacetyl)-alpha-D-glucopyranosylamine are not inhibitory | Oryctolagus cuniculus | |
N-(3-carboxypropanoyl)-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-(acetylcarbamoyl)-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-(azidoacetyl)-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-(benzoylcarbamoyl)-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-(dimethoxyphosphoryl)-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-(naphthalen-2-ylcarbonyl)-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-(trifluoroacetyl)-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-([4-[(benzyloxy)carbonyl]benzoyl]carbamoyl)-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-acetyl-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-carbamoyl-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-phenyl-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-[(4-aminobenzoyl)carbamoyl]-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-[(4-carboxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-[(4-chlorobenzoyl)carbamoyl]-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-[(4-hydroxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-[(4-methoxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-[(4-methylbenzoyl)carbamoyl]-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-[(4-nitrobenzoyl)carbamoyl]-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-[(biphenyl-4-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-[methoxy(oxo)acetyl]-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus | |
N-[[4-(methoxycarbonyl)benzoyl]carbamoyl]-beta-D-glucopyranosylamine | - |
Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | - |
Oryctolagus cuniculus | - |
Synonyms | Comment | Organism |
---|---|---|
glycogen phosphorylase b | - |
Oryctolagus cuniculus |
rmGPb | - |
Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0023 | - |
N-[(4-methylbenzoyl)carbamoyl]-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.0031 | - |
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.0032 | - |
N-[(4-methoxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.0033 | - |
N-[(4-nitrobenzoyl)carbamoyl]-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.0037 | - |
N-[(biphenyl-4-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.004 | - |
N-[[4-(methoxycarbonyl)benzoyl]carbamoyl]-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.0044 | - |
N-[(4-chlorobenzoyl)carbamoyl]-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.0046 | - |
N-(benzoylcarbamoyl)-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.0051 | - |
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.006 | - |
N-[(4-aminobenzoyl)carbamoyl]-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.0063 | - |
N-[(4-hydroxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.01 | - |
N-(naphthalen-2-ylcarbonyl)-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.02 | - |
N-(3-carboxypropanoyl)-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.032 | - |
N-acetyl-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.049 | - |
N-(azidoacetyl)-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.075 | - |
N-(trifluoroacetyl)-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.081 | - |
N-phenyl-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.085 | - |
N-[(4-carboxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.14 | - |
N-carbamoyl-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.15 | - |
N-([4-[(benzyloxy)carbonyl]benzoyl]carbamoyl)-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.21 | - |
N-[methoxy(oxo)acetyl]-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.32 | - |
(5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.37 | - |
N-(acetylcarbamoyl)-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
5.9 | - |
N-(dimethoxyphosphoryl)-beta-D-glucopyranosylamine | pH and temperature not specified in the publication | Oryctolagus cuniculus |