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Literature summary for 2.4.1.1 extracted from

  • Nagy, V.; Felfoeldi, N.; Konya, B.; Praly, J.P.; Docsa, T.; Gergely, P.; Chrysina, E.D.; Tiraidis, C.; Kosmopoulou, M.N.; Alexacou, K.M.; Konstantakaki, M.; Leonidas, D.D.; Zographos, S.E.; Oikonomakos, N.G.; Kozmon, S.; Tvaroska, I.; Somsak, L.
    N-(4-Substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods (2012), Bioorg. Med. Chem., 20, 1801-1816.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in complex with different inhibitory N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)urea compounds, X-ray diffraction structure determination and analysis at 1.8 A resolution, molecular modelling Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
(5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione
-
Oryctolagus cuniculus
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one
-
Oryctolagus cuniculus
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione
-
Oryctolagus cuniculus
additional information N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase, synthesis and evaluation by kinetic and crystallographic data, NMR structure analysis, molecular docking and modelling, overview. N-(trifluoroacetyl)-alpha-D-glucopyranosylamine and N-(trifluoroacetyl)-alpha-D-glucopyranosylamine are not inhibitory Oryctolagus cuniculus
N-(3-carboxypropanoyl)-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-(acetylcarbamoyl)-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-(azidoacetyl)-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-(benzoylcarbamoyl)-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-(dimethoxyphosphoryl)-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-(naphthalen-2-ylcarbonyl)-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-(trifluoroacetyl)-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-([4-[(benzyloxy)carbonyl]benzoyl]carbamoyl)-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-acetyl-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-carbamoyl-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-phenyl-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[(4-aminobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[(4-carboxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[(4-chlorobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[(4-hydroxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[(4-methoxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[(4-methylbenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[(4-nitrobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[(biphenyl-4-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[methoxy(oxo)acetyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[4-(methoxycarbonyl)benzoyl]carbamoyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Synonyms

Synonyms Comment Organism
glycogen phosphorylase b
-
Oryctolagus cuniculus
rmGPb
-
Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0023
-
N-[(4-methylbenzoyl)carbamoyl]-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.0031
-
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione pH and temperature not specified in the publication Oryctolagus cuniculus
0.0032
-
N-[(4-methoxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.0033
-
N-[(4-nitrobenzoyl)carbamoyl]-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.0037
-
N-[(biphenyl-4-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.004
-
N-[[4-(methoxycarbonyl)benzoyl]carbamoyl]-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.0044
-
N-[(4-chlorobenzoyl)carbamoyl]-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.0046
-
N-(benzoylcarbamoyl)-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.0051
-
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one pH and temperature not specified in the publication Oryctolagus cuniculus
0.006
-
N-[(4-aminobenzoyl)carbamoyl]-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.0063
-
N-[(4-hydroxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.01
-
N-(naphthalen-2-ylcarbonyl)-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.02
-
N-(3-carboxypropanoyl)-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.032
-
N-acetyl-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.049
-
N-(azidoacetyl)-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.075
-
N-(trifluoroacetyl)-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.081
-
N-phenyl-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.085
-
N-[(4-carboxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.14
-
N-carbamoyl-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.15
-
N-([4-[(benzyloxy)carbonyl]benzoyl]carbamoyl)-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.21
-
N-[methoxy(oxo)acetyl]-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.32
-
(5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione pH and temperature not specified in the publication Oryctolagus cuniculus
0.37
-
N-(acetylcarbamoyl)-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus
5.9
-
N-(dimethoxyphosphoryl)-beta-D-glucopyranosylamine pH and temperature not specified in the publication Oryctolagus cuniculus