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Literature summary for 2.4.1.1 extracted from

  • Bigley, A.N.; Reinhart, G.D.
    The N-terminus of glycogen phosphorylase b is not required for activation by adenosine 5-monophosphate (2010), Biochemistry, 49, 4760-4765.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
AMP quantification of the allosteric effect and the thermodynamic effect of AMP on phosphorylase b, overview Oryctolagus cuniculus
sulfate activates the wild-type but not the N-terminally truncated mutant Oryctolagus cuniculus

Application

Application Comment Organism
drug development glycogen phosphorylase is an active target of research in search of inhibitors for the treatment of type II diabetes Oryctolagus cuniculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of Pho1 in Escherichia coli strain DF1020 Oryctolagus cuniculus

Protein Variants

Protein Variants Comment Organism
additional information construction of an N-terminal truncated mutant DELTA2-17 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information allosteric kinetics, overview Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate Oryctolagus cuniculus
-
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
r

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate
-
Oryctolagus cuniculus [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
r

Synonyms

Synonyms Comment Organism
glycogen phosphorylase b
-
Oryctolagus cuniculus
phosphorylase a
-
Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at Oryctolagus cuniculus

General Information

General Information Comment Organism
additional information phosphorylase a is produced and isolated utilizing purified phosphorylase b and commercially available phosphorylase kinase Oryctolagus cuniculus