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Literature summary for 2.4.1.1 extracted from

  • Gregus, Z.; Nemeti, B.
    Glutathione-dependent reduction of arsenate by glycogen phosphorylase responsiveness to endogenous and xenobiotic inhibitors (2007), Toxicol. Sci., 100, 44-53.
    View publication on PubMed
Search for more literature for 2.4.1.1

Activating Compound

Activating Compound Comment Organism Structure
AMP activates Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
1,4-dideoxy-1,4-imino-D-arabinitol inhibits Pa-catalyzed As(V) reduction, inhibition of As(V) reduction is not influenced by glucose or AMP Oryctolagus cuniculus
ADP at physiological levels diminishes GPa-catalyzed As(V) reduction Oryctolagus cuniculus
ATP at physiological levels diminishes GPa-catalyzed As(V) reduction Oryctolagus cuniculus
BAY U6751 inhibits Pa-catalyzed As(V) reduction, glucose enhances inhibitory effect of the inhibitor on As(V) reduction, AMP at high concentration alleviates the inhibition Oryctolagus cuniculus
CP320626 inhibits Pa-catalyzed As(V) reduction, glucose enhances inhibitory effect of the inhibitor on As(V) reduction, AMP at high concentration alleviated the inhibition Oryctolagus cuniculus
glucose above 5 mM, diminishes GPa-catalyzed As(V) reduction Oryctolagus cuniculus
NEM inhibits GPa-catalyzed As(V) reduction Oryctolagus cuniculus
p-chloromercuribenzene sulfonate inhibits GPa-catalyzed As(V) reduction Oryctolagus cuniculus
quercetin inhibits Pa-catalyzed As(V) reduction, inhibition of As(V) reduction is not influenced by glucose or AMP Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GPa reduces arsenate (As(V)) to the more toxic arsenite (As(III)) in a glutathione (GSH)-dependent fashion Oryctolagus cuniculus ?
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 ?

Synonyms

Synonyms Comment Organism
glycogen phosphorylase-a
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 Oryctolagus cuniculus
GPA
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 Oryctolagus cuniculus