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Literature summary for 2.3.3.9 extracted from

  • de Freitas, C.S.; Kato, L.; de Oliveira, C.M.; Queiroz, L.H.; Santana, M.J.; Schuquel, I.T.; Delprete, P.G.; da Silva, R.A.; Quintino, G.O.; da Silva Neto, B.R.; Soares, C.M.; Pereira, M.
    beta-Carboline alkaloids from Galianthe ramosa inhibit malate synthase from Paracoccidioides spp (2014), Planta Med., 80, 1746-1752.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(1S,2S,3R)-2-(5-methoxy-9H-b-carbolin-1-yl)-1-methyl-3-(prop-1-en-2-yl)cyclopentanol
-
Paracoccidioides sp.
pyruvate
-
Paracoccidioides sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + H2O + glyoxylate Paracoccidioides sp.
-
(S)-malate + CoA
-
?

Organism

Organism UniProt Comment Textmining
Paracoccidioides sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + glyoxylate
-
Paracoccidioides sp. (S)-malate + CoA
-
?

Synonyms

Synonyms Comment Organism
malate synthase
-
Paracoccidioides sp.

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.05
-
at pH 7.0 and 35°C Paracoccidioides sp. (1S,2S,3R)-2-(5-methoxy-9H-b-carbolin-1-yl)-1-methyl-3-(prop-1-en-2-yl)cyclopentanol