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Literature summary for 2.3.3.9 extracted from

  • May, E.E.; Leitao, A.; Tropsha, A.; Oprea, T.I.
    A systems chemical biology study of malate synthase and isocitrate lyase inhibition in Mycobacterium tuberculosis during active and NRP growth (2013), Comput. Biol. Chem., 47, 167-180.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Bromopyruvate strong inhibitor Mycobacterium tuberculosis
glycolate weak inhibitor Mycobacterium tuberculosis
oxalate medium inhibitor Mycobacterium tuberculosis
phosphoenolpyruvate medium inhibitor Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + H2O + glyoxylate Mycobacterium tuberculosis
-
 (S)-malate + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + glyoxylate
-
 Mycobacterium tuberculosis (S)-malate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
glcB
-
 Mycobacterium tuberculosis
malate synthase
-
 Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.06
-
 Bromopyruvate pH and temperature not specified in the publication Mycobacterium tuberculosis
0.2
-
 phosphoenolpyruvate pH and temperature not specified in the publication Mycobacterium tuberculosis
0.4
-
 oxalate pH and temperature not specified in the publication Mycobacterium tuberculosis
0.9
-
 glycolate pH and temperature not specified in the publication Mycobacterium tuberculosis