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Literature summary for 2.3.3.8 extracted from
- Purification and physicochemical properties of ATP citrate (pro-3S) lyase from lactating rat mammary gland and studies of its reversible phosphorylation (1981), Eur. J. Biochem., 114, 399-405.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.011 | - |
CoA | phosphorylated enzyme | Rattus norvegicus |  |
| 0.18 | - |
citrate | phosphorylated enzyme | Rattus norvegicus | |
| 0.57 | - |
ATP | phosphorylated enzyme | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 116000 | - |
4 * 116000, SDS-PAGE | Rattus norvegicus |
| 473000 | - |
equilibrium sedimentation | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | phosphoprotein | Rattus norvegicus |
| side-chain modification | contains 2 mol phosphate per mol of tetramer | Rattus norvegicus |
| side-chain modification | regulation of the enzyme by reversible phosphorylation. The enzyme which has been phosphorylated by cyclic-AMP-dependent protein kinase, can be completely dephosphorylated by incubation with either protein phosphatase 1 or protein phosphatase 2 | Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| mammary gland | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mammary gland | lactating | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + citrate + CoA | - |
Rattus norvegicus | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 116000, SDS-PAGE | Rattus norvegicus |
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