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Literature summary for 2.3.3.5 extracted from

  • Liu, W.B.; Liu, X.X.; Shen, M.J.; She, G.L.; Ye, B.C.
    The nitrogen regulator GlnR directly controls transcription of the prpDBC operon involved in methylcitrate cycle in Mycobacterium smegmatis (2019), J. Bacteriol., 201, e00099-19 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.3.5

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
propanoyl-CoA + H2O + oxaloacetate Mycolicibacterium smegmatis the enzyme is specific to the methylcitrate cycle and essential for mycobacteria to grow on propionate as the sole carbon source (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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 ?

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propanoyl-CoA + H2O + oxaloacetate
-
 Mycolicibacterium smegmatis (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
-
 ?
propanoyl-CoA + H2O + oxaloacetate the enzyme is specific to the methylcitrate cycle and essential for mycobacteria to grow on propionate as the sole carbon source Mycolicibacterium smegmatis (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
MCS
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 Mycolicibacterium smegmatis
Methylcitrate synthase
-
 Mycolicibacterium smegmatis
PrpC
-
 Mycolicibacterium smegmatis

Expression

Organism Comment Expression
Mycolicibacterium smegmatis the nitrogen regulator GlnR regulates the methylcitrate cycle through direct repression of the transcription of the prpDBC operon down

General Information

General Information Comment Organism
metabolism the enzyme is specific to the methylcitrate cycle and essential for mycobacteria to grow on propionate as the sole carbon source Mycolicibacterium smegmatis