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Literature summary for 2.3.3.17 extracted from

  • Benderoth, M.; Pfalz, M.; Kroymann, J.
    Methylthioalkylmalate synthases: Genetics, ecology and evolution (2009), Phytochem. Rev., 8, 255-268.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an omega-(methylthio)-2-oxoalkanoate + acetyl-CoA + H2O Arabidopsis thaliana
-
a 2-[omega-(methylthio)alkyl]malate + CoA
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9FG67
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Arabidopsis thaliana
-
seed
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylthio-2-oxobutanoate + acetyl-CoA + H2O substrate for isoforms MAM1, MAM2, and MAM3 Arabidopsis thaliana 2-(2'-methylthioethyl)malate + CoA
-
?
5-methylthio-2-oxopentanoate + acetyl-CoA + H2O substrate for isoforms MAM1 and MAM3 Arabidopsis thaliana 2-(3'-methylthiopropyl)malate + CoA
-
?
6-methylthio-2-oxohexanoate + acetyl-CoA + H2O low activity substrate for isoforms MAM1 and MAM3 Arabidopsis thaliana 2-(4-methylthiobutyl)malate + CoA
-
?
7-methylthio-2-oxoheptanoate + acetyl-CoA + H2O substrate for isoform MAM3 Arabidopsis thaliana 2-(5-methylthiopentyl)malate + CoA
-
?
8-methylthio-2-oxooctanoate + acetyl-CoA + H2O substrate for isoform MAM3 Arabidopsis thaliana 2-(6-methylthiohexyl)malate + CoA
-
?
9-methylthio-2-oxononanoate + acetyl-CoA + H2O substrate for isoform MAM3 Arabidopsis thaliana 2-(7-methylthiohepyl)malate + CoA
-
?
an omega-(methylthio)-2-oxoalkanoate + acetyl-CoA + H2O
-
Arabidopsis thaliana a 2-[omega-(methylthio)alkyl]malate + CoA
-
?

Synonyms

Synonyms Comment Organism
MAM1 isoform Arabidopsis thaliana
MAM2 isoform Arabidopsis thaliana
MAM3 isoform Arabidopsis thaliana