Literature summary for 2.3.3.16 extracted from

Liu, X.; Ma, Q.; Sun, X.; Lu, M.; Ehsan, M.; Hasan, M.; Xu, L.; Yan, R.; Song, X.; Li, X.
Effects of recombinant Toxoplasma gondii citrate synthase I on the cellular functions of murine macrophages in vitro (2017), Front. Microbiol., 8, 1376 .

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Organism

Organism	UniProt	Comment	Textmining
Toxoplasma gondii	-	-	-

Subunits

Subunits	Comment	Organism
?	x * 60000, SDS-PAGE	Toxoplasma gondii

Synonyms

Synonyms	Comment	Organism
CSI	-	Toxoplasma gondii

General Information

General Information	Comment	Organism
physiological function	recombinant enzyme binds to murine macrophages, with low concentrations (5-10 microg/ml) enhancing phagocytosis and high levels (80 microg/ml) inhibiting phagocytosis. The secretion of interleukin-10, interleukin-1beta, transforming growth factor-beta1 and tumor necrosis factor-alpha of macrophages increase after the cells are incubated with CSI. Secretion of NO and cell proliferation of the macrophages are substantially reduced	Toxoplasma gondii

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Release 2023.1 (January 2023)