Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-Lys | 50 mM, 48% inhibition. Feed-back inhibition | Penicillium chrysogenum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + 2-oxoglutarate | Penicillium chrysogenum | first enzyme of the lysine biosynthetic pathway, feedback regulated by L-lysine. Maximum homocitrate synthase activity in cultures is found at 48 h, coinciding with the phase of high rate of penicillin biosynthesis | 2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penicillium chrysogenum | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mycelium | - |
Penicillium chrysogenum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + 2-oxoglutarate | - |
Penicillium chrysogenum | 2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? | |
acetyl-CoA + H2O + 2-oxoglutarate | first enzyme of the lysine biosynthetic pathway, feedback regulated by L-lysine. Maximum homocitrate synthase activity in cultures is found at 48 h, coinciding with the phase of high rate of penicillin biosynthesis | Penicillium chrysogenum | 2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? |