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Literature summary for 2.3.3.14 extracted from

  • Schmidt, H.; Bode, R.; Lindner, M.; Birnbaum, D.
    Lysine biosynthesis in the yeast Candida maltosa: properties of some enzymes and regulation of the biosynthetic pathway (1985), J. Basic Microbiol., 25, 675-681.
No PubMed abstract available
Search for more literature for 2.3.3.14

Inhibitors

Inhibitors Comment Organism Structure
Co2+
-
 Candida maltosa
DL-alpha-aminoadipate
-
 Candida maltosa
Hg2+
-
 Candida maltosa
L-Lys
-
 Candida maltosa
Mn2+
-
 Candida maltosa
thialysine L-thialysine Candida maltosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
 2-oxoglutarate
-
 Candida maltosa
0.033
-
 acetyl-CoA
-
 Candida maltosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + H2O + 2-oxoglutarate Candida maltosa
-
 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Candida maltosa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA sequential mechanism Candida maltosa
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + 2-oxoglutarate
-
 Candida maltosa 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 8.7
-
 Candida maltosa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5
-
 L-lysine
-
 Candida maltosa
5.1
-
 DL-alpha-aminoadipate
-
 Candida maltosa
15
-
 L-thialysine
-
 Candida maltosa