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Literature summary for 2.3.3.10 extracted from

  • Zhao, L.; Fan, J.; Xia, S.; Pan, Y.; Liu, S.; Qian, G.; Qian, Z.; Kang, H.B.; Arbiser, J.L.; Pollack, B.P.; Kudchadkar, R.R.; Lawson, D.H.; Rossi, M.; Abdel-Wahab, O.; Merghoub, T.; Khoury, H.J.; Khuri, F.R.; Boise, L.H.; Lonial, S.; Chen, F.; Chen, J.; Lin, R.
    HMG-CoA synthase 1 is a synthetic lethal partner of BRAFV600E in human cancers (2017), J. Biol. Chem., 292, 10142-10152 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the ketogenic HMG-CoA synthase 1/HMG-CoA lyase-acetoacetate axis may represent a promising therapeutic target for managing BRAFV600E-positive human cancers Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol cytosolic HMGCS1 that colocalizes with HMG-CoA lyase and BRAFV600E is more important than the mitochondrial HMGCS2 isoform in BRAFV600E-expressing cancer cells in terms of acetoacetate production Homo sapiens 5829
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q01581
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Source Tissue

Source Tissue Comment Organism Textmining
melanoma cell although HMGCS1 expression does not correlate with BRAFV600E mutation in human melanoma cells, HMGCS1 is selectively important for proliferation of BRAFV600E-positive melanoma and colon cancer cells but not control cells harboring activeN/KRAS mutants, and stable knockdown of HMGCS1 only attenuated colony formation and tumor growth potential of BRAFV600E melanoma cells Homo sapiens
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Synonyms

Synonyms Comment Organism
HMG-CoA synthase 1
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Homo sapiens
HMGCS1
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Homo sapiens

General Information

General Information Comment Organism
malfunction HMG-CoA synthase 1 knockdown causes a compensating increase in HMG-CoA lyase protein level because of attenuated protein degradation Homo sapiens