Application | Comment | Organism |
---|---|---|
medicine | the ketogenic HMG-CoA synthase 1/HMG-CoA lyase-acetoacetate axis may represent a promising therapeutic target for managing BRAFV600E-positive human cancers | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | cytosolic HMGCS1 that colocalizes with HMG-CoA lyase and BRAFV600E is more important than the mitochondrial HMGCS2 isoform in BRAFV600E-expressing cancer cells in terms of acetoacetate production | Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q01581 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
melanoma cell | although HMGCS1 expression does not correlate with BRAFV600E mutation in human melanoma cells, HMGCS1 is selectively important for proliferation of BRAFV600E-positive melanoma and colon cancer cells but not control cells harboring activeN/KRAS mutants, and stable knockdown of HMGCS1 only attenuated colony formation and tumor growth potential of BRAFV600E melanoma cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
HMG-CoA synthase 1 | - |
Homo sapiens |
HMGCS1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | HMG-CoA synthase 1 knockdown causes a compensating increase in HMG-CoA lyase protein level because of attenuated protein degradation | Homo sapiens |