Literature summary for 2.3.3.10 extracted from

Yi, W.; Fu, P.; Fan, Z.; Aso, H.; Tian, C.; Meng, Y.; Liu, J.; Yamori, Y.; Nara, Y.; Ying, C.
Mitochondrial HMG-CoA synthase partially contributes to antioxidant protection in the kidney of stroke-prone spontaneously hypertensive rats (2010), Nutrition, 26, 1176-1180.

Search for more literature for 2.3.3.10

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + H2O + acetoacetyl-CoA	Rattus norvegicus	-	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P22791	stroke-prone spontaneously hypertensive rats, SHRSPs, and their ancestral hypertensive but stroke-resistant spontaneously hypertensive rats, SHRs	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + H2O + acetoacetyl-CoA	-	Rattus norvegicus	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?

Synonyms

Synonyms	Comment	Organism
3-hydroxy-3-methylglutaryl-coenzyme A synthase	-	Rattus norvegicus
HMG-CoA synthase	-	Rattus norvegicus
HMGCS2	-	Rattus norvegicus
hydroxymethylglutaryl-CoA synthase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
CoA	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	lower renal expression of HMGCS2 in SHRSPs than in SHRs or clofibrate-treated SHRSPs	down

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Release 2023.1 (January 2023)