Application | Comment | Organism |
---|---|---|
medicine | target of a potent antisteroidogenic drug | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression vector pET-3d, cloned and expressed in Escherichia coli BL21 (DE3) | Gallus gallus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-carboxy-2,2,5,5,-tetramethyl-1-pyrrolidinyloxyl-CoA | - |
Gallus gallus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00055 | - |
acetoacetyl-CoA | mutant H197N | Gallus gallus | |
0.00062 | - |
acetoacetyl-CoA | mutant H436N | Gallus gallus | |
0.00085 | - |
acetoacetyl-CoA | - |
Gallus gallus | |
0.015 | - |
acetyl-CoA | acetyl-CoA hydrolysis | Gallus gallus | |
0.021 | - |
S-(3-oxobutyl)-CoA | - |
Gallus gallus | |
0.036 | - |
acetyl-CoA | mutant H264A, acetyl-CoA hydrolysis | Gallus gallus | |
0.038 | - |
acetyl-CoA | mutant H264N, acetyl-CoA hydrolysis | Gallus gallus | |
0.058 | - |
acetoacetyl-CoA | mutant H264N | Gallus gallus | |
0.115 | - |
acetoacetyl-CoA | mutant H264A | Gallus gallus | |
0.116 | - |
S-(3-oxobutyl)-CoA | mutant H264A | Gallus gallus | |
0.122 | - |
acetyl-CoA | mutant H264A | Gallus gallus | |
0.172 | - |
acetyl-CoA | mutant H264N | Gallus gallus | |
0.221 | - |
acetyl-CoA | mutant H436N | Gallus gallus | |
0.294 | - |
acetyl-CoA | - |
Gallus gallus | |
0.44 | - |
acetyl-CoA | mutant H197N | Gallus gallus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Gallus gallus | 5737 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Rattus norvegicus | 5737 | - |
cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
cytoplasm | - |
Bos taurus | 5737 | - |
mitochondrion | - |
Gallus gallus | 5739 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Bos taurus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | Gallus gallus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Mus musculus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Homo sapiens | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Rattus norvegicus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Saccharomyces cerevisiae | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Bos taurus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Mesocricetus auratus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Blattella germanica | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Blattella germanica | P54870 | cockroach, cytosolic isoform 2 | - |
Blattella germanica | P54961 | cockroach, cytosolic isoform 1 | - |
Bos taurus | - |
ox | - |
Gallus gallus | - |
avian | - |
Homo sapiens | - |
human | - |
Mesocricetus auratus | - |
syrian hamster, golden hamster | - |
Mus musculus | - |
mouse | - |
Rattus norvegicus | - |
rat | - |
Saccharomyces cerevisiae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Gallus gallus | - |
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-oxobutyryl-CoA + acetoacetyl-CoA + H2O | - |
Gallus gallus | 3-hydroxy-3-methyl-5-oxoheptanedioyl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Mus musculus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Rattus norvegicus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Saccharomyces cerevisiae | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Bos taurus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Mesocricetus auratus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Blattella germanica | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
H2O + acetyl-CoA + S-(3-oxobutyl)-CoA | - |
Gallus gallus | CoA + S-(4-carboxy-3-hydroxy-isoamyl)-CoA | - |
r |